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Issue 6, 2015
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Universal enantioselective discrimination by Raman spectroscopy

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Abstract

Distinguishing between the enantiomers of chiral substances and their quantification is an analytical challenge, in particular in the pharmaceutical and biochemical sectors. A Raman spectroscopic method for discrimination of enantiomers is proposed. Advantage is taken of the polarization properties when Raman scattering occurs in an optically active medium. It is shown that a conventional polarization-resolved Raman setup leads to identical spectra of the two enantiomers. However, inserting a half-wave retarder to rotate the signal polarization by a fixed angle enables the efficient and universal enantiomeric discrimination. Hence, the applicability of any polarization-resolved Raman experiment can be improved substantially without significant modification of the setup or the use of chiral labeling or the addition of a substrate for selective plasmonic enhancement. In principle, the proposed technique allows simultaneous speciation, enantiomeric discrimination, as well as structural and quantitative analysis.

Graphical abstract: Universal enantioselective discrimination by Raman spectroscopy

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Publication details

The article was received on 03 Dec 2014, accepted on 28 Jan 2015 and first published on 28 Jan 2015


Article type: Communication
DOI: 10.1039/C4AN02218A
Citation: Analyst, 2015,140, 1787-1790
  • Open access: Creative Commons BY license
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    Universal enantioselective discrimination by Raman spectroscopy

    J. Kiefer and K. Noack, Analyst, 2015, 140, 1787
    DOI: 10.1039/C4AN02218A

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