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Issue 2, 2014
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Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

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Abstract

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

Graphical abstract: Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

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Publication details

The article was received on 10 Jul 2013, accepted on 17 Oct 2013 and first published on 18 Oct 2013


Article type: Edge Article
DOI: 10.1039/C3SC51930A
Citation: Chem. Sci., 2014,5, 625-630
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    Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

    M. R. Reithofer, K. Chan, A. Lakshmanan, D. H. Lam, A. Mishra, B. Gopalan, M. Joshi, S. Wang and C. A. E. Hauser, Chem. Sci., 2014, 5, 625
    DOI: 10.1039/C3SC51930A

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