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Issue 7, 2014
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Conjugatable water-soluble Pt(II) and Pd(II) porphyrin complexes: novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering

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Abstract

Measurement of oxygen tension in compressed collagen sheets was performed using matrix-embedded optical oxygen sensors based on platinum(II) and palladium(II) porphyrins supported on polyacrylamide nanoparticles. Bespoke, fully water-soluble, mono-functionalised Pt(II) and Pd(II) porphyrin complexes designed for conjugation under mild conditions were obtained using microwave-assisted metallation. The new sensors display a linear response (1/τ vs. O2) to varying oxygen tension over a biologically relevant range (7.0 × 10−4 to 2.7 × 10−1 mM) in aqueous solutions; a behaviour that is maintained following conjugation to polyacrylamide nanoparticles, and following embedding of the nanosensors in compressed collagen sheets, paving the way to innovative approaches for real-time resolution of oxygen gradients throughout 3D matrices useful for tissue regeneration.

Graphical abstract: Conjugatable water-soluble Pt(ii) and Pd(ii) porphyrin complexes: novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering

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Publication details

The article was received on 29 Jan 2014, accepted on 30 Apr 2014 and first published on 30 Apr 2014


Article type: Paper
DOI: 10.1039/C4PP00026A
Author version available: Download Author version (PDF)
Citation: Photochem. Photobiol. Sci., 2014,13, 1039-1051
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    Conjugatable water-soluble Pt(II) and Pd(II) porphyrin complexes: novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering

    F. Giuntini, V. M. Chauhan, J. W. Aylott, G. A. Rosser, A. Athanasiadis, A. Beeby, A. J. MacRobert, R. A. Brown and R. W. Boyle, Photochem. Photobiol. Sci., 2014, 13, 1039
    DOI: 10.1039/C4PP00026A

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