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Issue 2, 2015
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Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells

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Abstract

Core–shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.

Graphical abstract: Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells

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Publication details

The article was received on 20 May 2014, accepted on 20 Jul 2014 and first published on 25 Jul 2014


Article type: Communication
DOI: 10.1039/C4NR02776K
Citation: Nanoscale, 2015,7, 415-420
  • Open access: Creative Commons BY-NC license
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    Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells

    J. Slegerova, M. Hajek, I. Rehor, F. Sedlak, J. Stursa, M. Hruby and P. Cigler, Nanoscale, 2015, 7, 415
    DOI: 10.1039/C4NR02776K

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