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Issue 10, 2014
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A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

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Abstract

This report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h−1, resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications.

Graphical abstract: A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

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Publication details

The article was received on 18 Jan 2014, accepted on 17 Feb 2014 and first published on 17 Feb 2014


Article type: Technical Innovation
DOI: 10.1039/C4LC00080C
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2014,14, 1673-1677
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    A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

    J. Wang, W. Chen, J. Sun, C. Liu, Q. Yin, L. Zhang, Y. Xianyu, X. Shi, G. Hu and X. Jiang, Lab Chip, 2014, 14, 1673
    DOI: 10.1039/C4LC00080C

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