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Issue 95, 2014
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An orthogonal photolabile linker for the complete “on-support” synthesis/fast deprotection/hybridization of RNA

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Abstract

The preparation of a polystyrene solid support decorated with a photolabile linker is described. The entire post-synthetic processing of RNA can be carried out in the solid phase in a minimum amount of time. The deprotected RNA is available for “on-support” hybridization and photolysis releases siRNA duplexes under mild, neutral conditions.

Graphical abstract: An orthogonal photolabile linker for the complete “on-support” synthesis/fast deprotection/hybridization of RNA

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Publication details

The article was received on 11 Sep 2014, accepted on 09 Oct 2014 and first published on 09 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC07153K
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 15063-15066
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    An orthogonal photolabile linker for the complete “on-support” synthesis/fast deprotection/hybridization of RNA

    J. Lietard, M. R. Hassler, J. Fakhoury and M. J. Damha, Chem. Commun., 2014, 50, 15063
    DOI: 10.1039/C4CC07153K

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