Issue 26, 2014
From the journal:

Chemical Communications

A label-free electrical assay of fibrous amyloid β based on semiconductor biosensing†

Sho Hideshima,a   Masumi Kobayashi,b   Takeyoshi Wada,c   Shigeki Kuroiwa,a   Takuya Nakanishi,a   Naoya Sawamura,c   Toru Asahiac  and  Tetsuya Osaka*ab  

* Corresponding authors

a Institute for Nanoscience & Nanotechnology, Waseda University, 513 Waseda-tsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan
E-mail: osakatets@waseda.jp
Fax: +81 3 3205 2074
Tel: +81 3 5286 3202

b Department of Nanoscience and Nanoengineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan

c Department of Life Science & Medical Bioscience, Waseda University, TWIns, 2-2 Wakamatsu, Shinjuku-ku, Tokyo 162-8480, Japan

Abstract

We propose, as an alternative to conventional spectroscopic assays, a simple method for discriminating fibrous amyloid proteins by using a label-free semiconductor-based biosensor. The highly sensitive assay is expected to be useful for accelerating amyloid related research.

Graphical abstract: A label-free electrical assay of fibrous amyloid β based on semiconductor biosensing

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Article information

DOI
https://doi.org/10.1039/C3CC49460H
Article type
Communication
Submitted
13 Dec 2013
Accepted
05 Feb 2014
First published
10 Feb 2014

Chem. Commun., 2014,50, 3476-3479

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A label-free electrical assay of fibrous amyloid β based on semiconductor biosensing

S. Hideshima, M. Kobayashi, T. Wada, S. Kuroiwa, T. Nakanishi, N. Sawamura, T. Asahi and T. Osaka, Chem. Commun., 2014, 50, 3476 DOI: 10.1039/C3CC49460H

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