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Issue 86, 2014
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Synthesis of N-aryl-1-aminoindoles via intermolecular redox amination

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Abstract

A redox amination strategy was developed for the synthesis of N-aryl-1-aminoindoles by N–N bond formation. Reaction of nitrosobenzenes with readily available indolines using Brønsted acid catalysis allows N–N bond formation under mild conditions. This method exploits the inherent reducing power of indoline to synthesize biologically relevant molecular architectures via redox amination. A one-pot synthesis of 1-aminoindoles starting from simple aniline and indolines is likewise described.

Graphical abstract: Synthesis of N-aryl-1-aminoindoles via intermolecular redox amination

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Publication details

The article was received on 13 Aug 2014, accepted on 02 Sep 2014 and first published on 05 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC06369D
Citation: Chem. Commun., 2014,50, 13056-13058
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    Synthesis of N-aryl-1-aminoindoles via intermolecular redox amination

    K. Ramakumar and J. A. Tunge, Chem. Commun., 2014, 50, 13056
    DOI: 10.1039/C4CC06369D

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