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Issue 23, 2014
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A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd0 nanoparticles?

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Abstract

A Pd-mediated direct C–H bond functionalisation of tryptophan has been developed, both as a single amino acid residue and within peptides. Important mechanistic insight into this process has been gained by characterising a Pd catalytically competent nanoparticle phase which evolves during the early stages of reaction.

Graphical abstract: A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd0 nanoparticles?

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Publication details

The article was received on 06 Nov 2013, accepted on 25 Jan 2014 and first published on 10 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC48481E
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Citation: Chem. Commun., 2014,50, 3052-3054
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    A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd0 nanoparticles?

    T. J. Williams, A. J. Reay, A. C. Whitwood and I. J. S. Fairlamb, Chem. Commun., 2014, 50, 3052
    DOI: 10.1039/C3CC48481E

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