Jump to main content
Jump to site search

Issue 15, 2014
Previous Article Next Article

Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate

Author affiliations

Abstract

The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4–0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.

Graphical abstract: Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Nov 2013, accepted on 26 Nov 2013 and first published on 08 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC48466A
Citation: Chem. Commun., 2014,50, 1817-1819
  • Open access: Creative Commons BY license
  •   Request permissions

    Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate

    F. P. A. Fabbiani, G. Buth, D. C. Levendis and A. J. Cruz-Cabeza, Chem. Commun., 2014, 50, 1817
    DOI: 10.1039/C3CC48466A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements