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Issue 19, 2013
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Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks

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Abstract

We demonstrate the contactless generation of lipid nanotube networks by means of thermally induced migration of flat giant unilamellar vesicles (FGUVs), covering micro-scale areas on oxidized aluminum surfaces. A temperature gradient with a reach of 20 μm was generated using a focused IR laser, leading to a surface adhesion gradient, along which FGUVs could be relocated. We report on suitable lipid–substrate combinations, highlighting the critical importance of the electrostatic interactions between the engineered substrate and the membrane for reversible migration of intact vesicles.

Graphical abstract: Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks

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Publication details

The article was received on 27 Mar 2013, accepted on 21 Jun 2013 and first published on 26 Jun 2013


Article type: Technical Innovation
DOI: 10.1039/C3LC50391G
Citation: Lab Chip, 2013,13, 3822-3826
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    Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks

    I. Gözen, M. Shaali, A. Ainla, B. Örtmen, I. Põldsalu, K. Kustanovich, G. D. M. Jeffries, Z. Konkoli, P. Dommersnes and A. Jesorka, Lab Chip, 2013, 13, 3822
    DOI: 10.1039/C3LC50391G

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