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Issue 28, 2013
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Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate

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Abstract

Reaction of Bi(OtBu)3 with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(III) complex, [Bi(O2C(C6H4)OAc)3] 1 (O2C(C6H4)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori ≥ 6.25 μg mL−1, while the inclusion of a stoichiometric equivalent of KOtBu leads to crystals of the bismuthate salt [KBi(O2C(C6H4)OAc)4] 2.

Graphical abstract: Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(iii) acetylsalicylate

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Publication details

The article was received on 25 Jan 2013, accepted on 21 Feb 2013 and first published on 22 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC40645H
Citation: Chem. Commun., 2013,49, 2870-2872
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    Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate

    P. C. Andrews, V. L. Blair, R. L. Ferrero, P. C. Junk and I. Kumar, Chem. Commun., 2013, 49, 2870
    DOI: 10.1039/C3CC40645H

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