Issue 28, 2013

Polymerization of a peptide-based enzyme substrate

Abstract

Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.

Graphical abstract: Polymerization of a peptide-based enzyme substrate

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2013
Accepted
18 Feb 2013
First published
01 Mar 2013

Chem. Commun., 2013,49, 2873-2875

Polymerization of a peptide-based enzyme substrate

M. E. Hahn, L. M. Randolph, L. Adamiak, M. P. Thompson and N. C. Gianneschi, Chem. Commun., 2013, 49, 2873 DOI: 10.1039/C3CC40472B

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