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Issue 23, 2012
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Evidence for membrane flow through pores in stacked phospholipid membranes

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Abstract

We present evidence for an inter-bilayer transport mode of lipid molecules in solid-supported double bilayer membranes via membrane defects. The observation of avalanche rupturing in isolated membrane areas of flat giant unilamellar vesicles, i.e., double bilayers, in the distal (with respect to the solid support) bilayer revealed migration of the membrane material between the stacked bilayers, which we can explain by the presence of defects. The presence of the interconnections was indirectly observed by monitoring the area development of the isolated membrane patches during rupturing. These new findings can help to better describe the dynamic processes in biological structures, featuring stacks of phospholipid bilayers, such as mitochondrial shape dynamics.

Graphical abstract: Evidence for membrane flow through pores in stacked phospholipid membranes

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Publication details

The article was received on 18 Mar 2012, accepted on 10 Apr 2012 and first published on 16 May 2012


Article type: Paper
DOI: 10.1039/C2SM25629K
Citation: Soft Matter, 2012,8, 6220-6225
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    Evidence for membrane flow through pores in stacked phospholipid membranes

    I. Gozen, P. Dommersnes, O. Orwar and A. Jesorka, Soft Matter, 2012, 8, 6220
    DOI: 10.1039/C2SM25629K

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