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Issue 28, 2012
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A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

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Abstract

Optical imaging provides an indispensable way to locate tumors in their early stages with high sensitivity and signal to background ratio. A heptamethine cyanine based fluorophore that emits both single photon near-infrared fluorescence and two-photon deep red fluorescence under physiological conditions was developed. Linear and nonlinear photophysical properties of this fluorophore were investigated and it demonstrated the capability to label lysosomes in cancer cells. The advantages of this fluorophore, including tolerable cytotoxicity, high fluorescence quantum yield, and the ability to emit both near-infrared single photon fluorescence and deep red two photon fluorescence in aqueous solution, give it potential to be used in intra-operatively optical image-guided tumor excision followed by two-photon fluorescence microscopy biopsy analysis after a single administration.

Graphical abstract: A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

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Publication details

The article was received on 26 Mar 2012, accepted on 30 May 2012 and first published on 01 Jun 2012


Article type: Paper
DOI: 10.1039/C2OB25619C
Citation: Org. Biomol. Chem., 2012,10, 5366-5370
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    A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

    L. Wang, J. Jin, X. Chen, H. Fan, B. K. F. Li, K. Cheah, N. Ding, S. Ju, W. Wong and C. Li, Org. Biomol. Chem., 2012, 10, 5366
    DOI: 10.1039/C2OB25619C

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