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Issue 28, 2012
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New domino heteroannulation of enaminones: synthesis of diverse fused naphthyridines

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Abstract

A series of new poly-functionalized fused naphthyridine derivatives were synthesized via a three-component reaction of aldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and enaminone in EtOH using EtONa as a base. During these reaction processes, the domino construction of fused naphthyridine skeleton with concomitant formation of two new pyridine rings was readily achieved via base promoted three-component reactions in a one-pot operation. The procedures are facile, avoiding time-consuming and costly syntheses, tedious work-up and purifications of precursors.

Graphical abstract: New domino heteroannulation of enaminones: synthesis of diverse fused naphthyridines

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Publication details

The article was received on 18 Feb 2012, accepted on 11 Apr 2012 and first published on 16 Apr 2012


Article type: Paper
DOI: 10.1039/C2OB25349F
Citation: Org. Biomol. Chem., 2012,10, 5361-5365
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    New domino heteroannulation of enaminones: synthesis of diverse fused naphthyridines

    J. Li, Y. Yu, M. Tu, B. Jiang, S. Wang and S. Tu, Org. Biomol. Chem., 2012, 10, 5361
    DOI: 10.1039/C2OB25349F

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