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Issue 19, 2012
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Copper(II)-mediated oxidative cyclization of enamides to oxazoles

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Abstract

The copper(II)-mediated oxidative cyclization of enamides to oxazoles is reported. A range of 2,5-disubstituted oxazoles were prepared in moderate to good yields in two steps from simple amide and alkyne precursors.

Graphical abstract: Copper(ii)-mediated oxidative cyclization of enamides to oxazoles

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Publication details

The article was received on 11 Feb 2012, accepted on 22 Mar 2012 and first published on 23 Mar 2012


Article type: Paper
DOI: 10.1039/C2OB25310K
Citation: Org. Biomol. Chem., 2012,10, 3866-3870
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    Copper(II)-mediated oxidative cyclization of enamides to oxazoles

    A. E. Wendlandt and S. S. Stahl, Org. Biomol. Chem., 2012, 10, 3866
    DOI: 10.1039/C2OB25310K

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