The copper(II)-mediated oxidative cyclization of enamides to oxazoles is reported. A range of 2,5-disubstituted oxazoles were prepared in moderate to good yields in two steps from simple amide and alkyne precursors.
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Copper(II)-mediated oxidative cyclization of enamides to oxazoles
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Department of Chemistry, University of Wisconsin – Madison, 1101 University Ave, Madison, USA
E-mail: stahl@chem.wisc.edu ;
Fax: +1 608 262 6143 ;
Tel: +1 608 265 6288
E-mail: stahl@chem.wisc.edu ;
Fax: +1 608 262 6143 ;
Tel: +1 608 265 6288
Org. Biomol. Chem., 2012,10, 3866-3870
DOI: 10.1039/C2OB25310K
Received 11 Feb 2012, Accepted 22 Mar 2012
First published online 23 Mar 2012
Organic & Biomolecular Chemistry
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