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Issue 19, 2012
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Single-step radiofluorination of peptides using continuous flow microreactor

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Abstract

18F radiolabelling of peptides bearing two different prosthetic groups was successfully conducted in a continuous flow microfluidic device for the first time. Radiochemical yields were dependent on precursor concentration, reaction temperature and flow rate. The choice of leaving group had a dramatic influence on the reaction outcome. Rapid reaction optimization was possible.

Graphical abstract: Single-step radiofluorination of peptides using continuous flow microreactor

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Publication details

The article was received on 03 Jan 2012, accepted on 23 Mar 2012 and first published on 23 Mar 2012


Article type: Paper
DOI: 10.1039/C2OB00015F
Citation: Org. Biomol. Chem., 2012,10, 3871-3874
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    Single-step radiofluorination of peptides using continuous flow microreactor

    S. V. Selivanova, L. Mu, J. Ungersboeck, T. Stellfeld, S. M. Ametamey, R. Schibli and W. Wadsak, Org. Biomol. Chem., 2012, 10, 3871
    DOI: 10.1039/C2OB00015F

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