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Issue 17, 2012
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Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates

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Abstract

The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated using benzylamine as amine component. The products obtained from this biotransformation in high enantiomeric purity can serve as valuable precursors for various amino alcohols, as exemplified by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine.

Graphical abstract: Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates

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Publication details

The article was received on 02 Feb 2012, accepted on 08 Mar 2012 and first published on 09 Mar 2012


Article type: Communication
DOI: 10.1039/C2OB25247C
Citation: Org. Biomol. Chem., 2012,10, 3384-3387
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    Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates

    A. Prechter, H. Gröger and M. R. Heinrich, Org. Biomol. Chem., 2012, 10, 3384
    DOI: 10.1039/C2OB25247C

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