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Issue 1, 2012
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Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives

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Abstract

We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation of the naphthyridine ligands with a series of guanosine nucleotides was investigated, and it is shown that the POSS core should play a significant role in the stabilization of the complexes via hydrogen bonds. Finally, we demonstrate that the 1,8-naphthyridine ligand can selectively recognize guanosine triphosphate by assisting with the POSS-core dendrimer.

Graphical abstract: Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives

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Publication details

The article was received on 24 Sep 2011, accepted on 12 Oct 2011 and first published on 01 Nov 2011


Article type: Paper
DOI: 10.1039/C1OB06630G
Citation: Org. Biomol. Chem., 2012,10, 90-95
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    Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives

    K. Tanaka, M. Murakami, J. Jeon and Y. Chujo, Org. Biomol. Chem., 2012, 10, 90
    DOI: 10.1039/C1OB06630G

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