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Issue 7, 2012
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Experimental and theoretical evaluation of nanodiamonds as pH triggered drug carriers

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Abstract

Nanodiamond (ND) and its derivatives have been widely used for drug, protein and gene delivery. Herein, experimental and theoretical methods have been combined to investigate the effect of pH on the delivery of doxorubicin (DOX) from fluorescein labeled NDs (Fc-NDs). In the endosomal recycling process, the nanoparticle will pass from mildly acidic vesicle to pH ≈ 4.8; thus, it is important to investigate DOX release from NDs at different pH values. Fc-NDs released DOX dramatically under acidic conditions, while an increase in the DOX loading efficiency (up to 6.4 wt%) was observed under basic conditions. Further theoretical calculations suggest that H+ weakens the electrostatistic interaction between ND surface carboxyl groups and DOX amino groups, and the interaction energies at pH < 7, pH 7 and pH > 7 are 10.4 kcal mol−1, 25.0 kcal mol−1 and 27.0 kcal mol−1 respectively. Cellular imaging experiments show that Fc-NDs are readily ingested by breast adenocarcinoma (BA) cells and cell viability tests prove that they can be utilized as a safe drug delivery vehicle. Furthermore, pH triggered DOX release has been tested in vitro (pH 7.4 and pH 4.83) in breast adenocarcinoma (BA) cells.

Graphical abstract: Experimental and theoretical evaluation of nanodiamonds as pH triggered drug carriers

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Publication details

The article was received on 22 Mar 2012, accepted on 27 Mar 2012 and first published on 02 Apr 2012


Article type: Paper
DOI: 10.1039/C2NJ40226B
Citation: New J. Chem., 2012,36, 1479-1484
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    Experimental and theoretical evaluation of nanodiamonds as pH triggered drug carriers

    J. Yan, Y. Guo, A. Altawashi, B. Moosa, S. Lecommandoux and N. M. Khashab, New J. Chem., 2012, 36, 1479
    DOI: 10.1039/C2NJ40226B

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