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Issue 13, 2012
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In search of a treatment for HIV – current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

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Abstract

The human immunodeficiency virus (HIV) causes AIDS (acquired immune deficiency syndrome), a disease in which the immune system progressively deteriorates, making sufferers vulnerable to all manner of opportunistic infections. Currently, world-wide there are estimated to be 34 million people living with HIV, with the vast majority of these living in sub-Saharan Africa. Therefore, an important research focus is development of new drugs that can be used in the treatment of HIV/AIDS. This review gives an overview of the disease and addresses the drugs currently used for treatment, with specific emphasis on new developments within the class of allosteric non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Graphical abstract: In search of a treatment for HIV – current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

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Publication details

The article was received on 29 Feb 2012 and first published on 22 May 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS35058K
Citation: Chem. Soc. Rev., 2012,41, 4657-4670
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    In search of a treatment for HIV – current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

    C. Reynolds, C. B. de Koning, S. C. Pelly, W. A. L. van Otterlo and M. L. Bode, Chem. Soc. Rev., 2012, 41, 4657
    DOI: 10.1039/C2CS35058K

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