The use of the electron-rich diphosphine ligand, dcpe, allows the efficient and highly linear selective hydroacylative coupling of aldehydes, including aryl examples, with a range of alkynes.
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Rhodium-catalysed linear-selective alkyne hydroacylation
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a
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK
E-mail: michael.willis@chem.ox.ac.uk ;
Fax: 44 1865 285002 ;
Tel: 44 1865 285126
E-mail: michael.willis@chem.ox.ac.uk ;
Fax: 44 1865 285002 ;
Tel: 44 1865 285126
b
EpiNova DPU, Immuno-Inflammation TAU, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, UK
Chem. Commun., 2012,48, 6354-6356
DOI: 10.1039/C2CC32713A
Received 17 Apr 2012, Accepted 03 May 2012
First published online 04 May 2012
Chemical Communications
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