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Issue 51, 2012
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Synthesis of a glycopolymeric PtII carrier and its induction of apoptosis in resistant cancer cells

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Abstract

Post-polymerization modification of a poly(pentafluorostyryl) backbone with β-D-galactose and a terpyridine platinum complex yields a well-defined material that represents the first example of a metal-conjugated glycopolymer. It reveals anti-proliferative activity, no detectable necrotic cytotoxicity, and efficiently induces apoptosis in both wild-type as well as resistant Nalm-6 leukemia cell lines.

Graphical abstract: Synthesis of a glycopolymeric PtII carrier and its induction of apoptosis in resistant cancer cells

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Publication details

The article was received on 20 Feb 2012, accepted on 03 May 2012 and first published on 03 May 2012


Article type: Communication
DOI: 10.1039/C2CC31275A
Citation: Chem. Commun., 2012,48, 6357-6359
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    Synthesis of a glycopolymeric PtII carrier and its induction of apoptosis in resistant cancer cells

    A. Wild, K. Babiuch, M. König, A. Winter, M. D. Hager, M. Gottschaldt, A. Prokop and U. S. Schubert, Chem. Commun., 2012, 48, 6357
    DOI: 10.1039/C2CC31275A

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