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Issue 6, 2012
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Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

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Abstract

In contrast to the Pt(IV) derivatives of cisplatin, Pt(IV) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.

Graphical abstract: Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

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Publication details

The article was received on 26 Oct 2011, accepted on 17 Nov 2011 and first published on 29 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16647F
Citation: Chem. Commun., 2012,48, 847-849
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    Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

    J. Z. Zhang, E. Wexselblatt, T. W. Hambley and D. Gibson, Chem. Commun., 2012, 48, 847
    DOI: 10.1039/C1CC16647F

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