Issue 4, 2012
From the journal:

Chemical Communications

Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

Keunhong Jeong,*a   Hye Rim Cho,b   Seung Hong Choi,b   Yangki Parka  and  Pil Seok Chaec  

* Corresponding authors

a Department of Chemistry, Korea Military Academy, Seoul 139-799, South Korea
E-mail: doas1mind@kma.ac.kr
Fax: +82 2 972 8179
Tel: +82 2 2197 2845

b Department of Radiology, Seoul National University Hospital, Seoul 110-744, South Korea

c Department of Bionano Engineering, Hanyang University, Ansan 426-791, Korea

Abstract

Cleavage agents showed cleavage yields as much as 9–14%, which does not sufficiently support the agents' protection of β-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents.

Graphical abstract: Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

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Article information

DOI
https://doi.org/10.1039/C1CC16293D
Article type
Communication
Submitted
10 Oct 2011
Accepted
11 Nov 2011
First published
23 Nov 2011

Chem. Commun., 2012,48, 588-590

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Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

K. Jeong, H. R. Cho, S. H. Choi, Y. Park and P. S. Chae, Chem. Commun., 2012, 48, 588 DOI: 10.1039/C1CC16293D

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