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Issue 15, 2011
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Novel α-arylnitriles synthesis via Ni-catalyzed cross-coupling of α-bromonitriles with arylboronic acids under mild conditions

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Abstract

An applicable and easy-handling Ni-catalyst can be used to promote direct arylation of α-bromonitriles with various arylboronic acids to construct α-arylnitriles under mild conditions. The methodology tolerates β-hydrogens and functional groups in the substrates.

Graphical abstract: Novel α-arylnitriles synthesis via Ni-catalyzed cross-coupling of α-bromonitriles with arylboronic acids under mild conditions

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Publication details

The article was received on 01 Mar 2011, accepted on 12 May 2011 and first published on 12 May 2011


Article type: Communication
DOI: 10.1039/C1OB05326D
Citation: Org. Biomol. Chem., 2011,9, 5343-5345
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    Novel α-arylnitriles synthesis via Ni-catalyzed cross-coupling of α-bromonitriles with arylboronic acids under mild conditions

    Y. Yang, S. Tang, C. Liu, H. Zhang, Z. Sun and A. Lei, Org. Biomol. Chem., 2011, 9, 5343
    DOI: 10.1039/C1OB05326D

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