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Issue 3, 2011
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γ-AApeptides: design, synthesis and evaluation

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Abstract

A new class of peptide mimics termed “γ-AApeptides” has been described. The design and synthesis of γ-AApeptides, and potential bioactivities towards p53/MDM2 interaction were demonstrated. γ-AApeptides were also found to be highly resistant to proteolysis. The development of sequence-specific γ-AApeptides may lead to a family of peptidomimetics with a new framework for drug discovery or peptide/protein mimicry.

Graphical abstract: γ-AApeptides: design, synthesis and evaluation

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Publication details

The article was received on 30 Nov 2010, accepted on 12 Jan 2011 and first published on 31 Jan 2011


Article type: Letter
DOI: 10.1039/C0NJ00943A
Citation: New J. Chem., 2011,35, 542-545
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    γ-AApeptides: design, synthesis and evaluation

    Y. Niu, Y. Hu, X. Li, J. Chen and J. Cai, New J. Chem., 2011, 35, 542
    DOI: 10.1039/C0NJ00943A

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