Issue 3, 2011
From the journal:

New Journal of Chemistry

γ-AApeptides: design, synthesis and evaluation†

Youhong Niu,a   Yaogang Hu,a   Xiaolong Li,b   Jiandong Chenb  and  Jianfeng Cai*a  

* Corresponding authors

a Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, USA
E-mail: jianfengcai@usf.edu
Fax: +1 813-974-3203
Tel: +1 813-974-9506

b Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, USA

Abstract

A new class of peptide mimics termed “γ-AApeptides” has been described. The design and synthesis of γ-AApeptides, and potential bioactivities towards p53/MDM2 interaction were demonstrated. γ-AApeptides were also found to be highly resistant to proteolysis. The development of sequence-specific γ-AApeptides may lead to a family of peptidomimetics with a new framework for drug discovery or peptide/protein mimicry.

Graphical abstract: γ-AApeptides: design, synthesis and evaluation

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Article information

DOI
https://doi.org/10.1039/C0NJ00943A
Article type
Letter
Submitted
30 Nov 2010
Accepted
12 Jan 2011
First published
31 Jan 2011

New J. Chem., 2011,35, 542-545

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γ-AApeptides: design, synthesis and evaluation

Y. Niu, Y. Hu, X. Li, J. Chen and J. Cai, New J. Chem., 2011, 35, 542 DOI: 10.1039/C0NJ00943A

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