Jump to main content
Jump to site search

Issue 3, 2011
Previous Article Next Article

Gas-phase H/D-exchange experiments in supramolecular chemistry

Author affiliations

Abstract

This review discusses the potential of gas-phase H/D-exchange (HDX) reactions for supramolecular chemistry. The exchange of labile H against D atoms can help unravel structural details of supramolecules—in particular when combined with other gas-phase experiments, e.g. ion-mobility MS. The presence of different, non-interconverting structures in an ion population can lead to bimodal exchange distributions. Since hydrogen bonding has an effect on the exchange rates, the number and positions of hydrogen bonds can often be determined. Zwitterionic and charge-solvated structures of amino acids and peptides can be distinguished. Beyond structure, dynamic features such as the mobility of building blocks within complexes can be investigated.

Graphical abstract: Gas-phase H/D-exchange experiments in supramolecular chemistry

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 13 Aug 2010, accepted on 15 Nov 2010 and first published on 22 Dec 2010


Article type: Perspective
DOI: 10.1039/C0NJ00634C
Citation: New J. Chem., 2011,35, 529-541
  •   Request permissions

    Gas-phase H/D-exchange experiments in supramolecular chemistry

    H. D. F. Winkler, E. V. Dzyuba and C. A. Schalley, New J. Chem., 2011, 35, 529
    DOI: 10.1039/C0NJ00634C

Search articles by author