Jump to main content
Jump to site search

Issue 3, 2011
Previous Article Next Article

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

Author affiliations

Abstract

A series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse model, and was selected for further pre-clinical evaluation as a potential treatment for hepatitis C viral infection.

Graphical abstract: The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Nov 2010, accepted on 03 Dec 2010 and first published on 20 Dec 2010


Article type: Concise Article
DOI: 10.1039/C0MD00197J
Citation: Med. Chem. Commun., 2011,2, 185-189
  •   Request permissions

    The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

    D. C. Pryde, T. Tran, P. Jones, G. C. Parsons, G. Bish, F. M. Adam, M. C. Smith, D. S. Middleton, N. N. Smith, F. Calo, D. Hay, M. Paradowski, K. J. W. Proctor, T. Parkinson, C. Laxton, D. N. A. Fox, N. J. Horscroft, G. Ciaramella, H. M. Jones, J. Duckworth, N. Benson, A. Harrison and R. Webster, Med. Chem. Commun., 2011, 2, 185
    DOI: 10.1039/C0MD00197J

Search articles by author

Spotlight

Advertisements