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Issue 3, 2011
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Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives

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Abstract

With the purpose to improve the biological activities of curcumin, eight novel ferrocenyl curcuminoids were synthesized by covalent anchorage of three different ferrocenyl ligands. We evaluated their cytotoxicity on B16 melanoma cells and normal NIH 3T3 cells, their inhibition of tubulin polymerization and their effect on the morphology of endothelial cells. The presence of a ferrocenyl side chain was clearly shown to improve the biological activity of most of their corresponding organic curcuminoid analogues.

Graphical abstract: Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives

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Publication details

The article was received on 22 Nov 2010, accepted on 21 Dec 2010 and first published on 11 Jan 2011


Article type: Concise Article
DOI: 10.1039/C0MD00231C
Citation: Med. Chem. Commun., 2011,2, 190-195
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    Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives

    A. Arezki, G. G. Chabot, L. Quentin, D. Scherman, G. Jaouen and E. Brulé, Med. Chem. Commun., 2011, 2, 190
    DOI: 10.1039/C0MD00231C

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