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Issue 5, 2011
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Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)

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Abstract

We present a self-powered integrated microfluidic blood analysis system (SIMBAS) that does not require any external connections, tethers, or tubing to deliver and analyze a raw whole-blood sample. SIMBAS only requires the user to place a 5 μL droplet of whole-blood at the inlet port of the device, whereupon the stand-alone SIMBAS performs on-chip removal of red and white cells, without external valving or pumping mechanisms, followed by analyte detection in platelet-containing plasma. Five complete biotin–streptavidin sample-to-answer assays are performed in 10 min; the limit of detection is 1.5 pM. Red and white blood cells are removed by trapping them in an integral trench structure. Simulations and experimental data show 99.9% to 100% blood cell retention in the passive structure. Powered by pre-evacuation of its PDMS substrate, SIMBAS' guiding design principle is the integration of the minimal number of components without sacrificing effectiveness in performing rapid complete bioassays, a critical step towards point-of-care molecular diagnostics.

Graphical abstract: Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)

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Publication details

The article was received on 12 Sep 2010, accepted on 19 Oct 2010 and first published on 08 Dec 2010


Article type: Paper
DOI: 10.1039/C0LC00403K
Citation: Lab Chip, 2011,11, 845-850
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    Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)

    I. K. Dimov, L. Basabe-Desmonts, J. L. Garcia-Cordero, B. M. Ross, A. J. Ricco and L. P. Lee, Lab Chip, 2011, 11, 845
    DOI: 10.1039/C0LC00403K

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