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Issue 4, 2011
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5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications

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Abstract

The biorefinery is an important approach for the current needs of energy and chemical building blocks for a diverse range of applications, that gradually may replace current dependence on fossil-fuel resources. Among other primary renewable building blocks, 5-hydroxymethylfurfural (HMF) is considered an important intermediate due to its rich chemistry and potential availability from carbohydrates such as fructose, glucose, sucrose, cellulose and inulin. In recent years, considerable efforts have been made on the transformation of carbohydrates into HMF. In this critical review we provide an overview of the effects of HMF on microorganisms and humans, HMF production and functional group transformations of HMF to relevant target molecules by taking advantage of the primary hydroxyl, aldehyde and furan functionalities.

Graphical abstract: 5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications

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Publication details

The article was received on 05 Aug 2010, accepted on 15 Dec 2010 and first published on 28 Feb 2011


Article type: Critical Review
DOI: 10.1039/C0GC00401D
Citation: Green Chem., 2011,13, 754-793
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    5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications

    A. A. Rosatella, S. P. Simeonov, R. F. M. Frade and C. A. M. Afonso, Green Chem., 2011, 13, 754
    DOI: 10.1039/C0GC00401D

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