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Issue 16, 2011
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c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

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Abstract

The ubiquitous bacterial biofilm regulator, c-di-GMP can form G-quadruplexes at physiological conditions in the presence of some aromatic compounds, such as acriflavine and proflavine. The fluorescence of these compounds is quenched upon c-di-GMP binding and some of the formed c-di-GMP G-quadruplexes are stable even at 75 °C.

Graphical abstract: c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

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Publication details

The article was received on 07 Dec 2010, accepted on 24 Feb 2011 and first published on 14 Mar 2011


Article type: Communication
DOI: 10.1039/C0CC05432A
Citation: Chem. Commun., 2011,47, 4766-4768
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    c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

    S. Nakayama, I. Kelsey, J. Wang and H. O. Sintim, Chem. Commun., 2011, 47, 4766
    DOI: 10.1039/C0CC05432A

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