Issue 2, 2011
From the journal:

Chemical Communications

Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons†

Jia Liu,a   Chung-Hang Leung,a   Andy Lok-Fung Chow,a   Raymond Wai-Yin Sun,a   Siu-Cheong Yanb  and  Chi-Ming Che*a  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: +852 2857 1586
Tel: +852 2857 2154

b Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

Abstract

A platinum(II)-based major groove binder [PtII(C⁁N)(C[triple bond, length as m-dash]NR)2]+ (HC⁁N = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase IIα poison. It stabilizes the covalent TopoIIα–DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoIIα poison Vp-16.

Graphical abstract: Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons

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Article information

DOI
https://doi.org/10.1039/C0CC03641B
Article type
Communication
Submitted
03 Sep 2010
Accepted
20 Oct 2010
First published
11 Nov 2010

Chem. Commun., 2011,47, 719-721

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Cyclometalated platinum(II) complexes as topoisomerase IIα poisons

J. Liu, C. Leung, A. L. Chow, R. W. Sun, S. Yan and C. Che, Chem. Commun., 2011, 47, 719 DOI: 10.1039/C0CC03641B

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