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Issue 3, 2011
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Dynamic combinatorial libraries: new opportunities in systems chemistry

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Abstract

Combinatorial chemistry is a tool for selecting molecules with special properties. Dynamic combinatorial chemistry started off aiming to be just that. However, unlike ordinary combinatorial chemistry, the interconnectedness of dynamic libraries gives them an extra dimension. An understanding of these molecular networks at systems level is essential for their use as a selection tool and creates exciting new opportunities in systems chemistry. In this feature article we discuss selected examples and considerations related to the advanced exploitation of dynamic combinatorial libraries for their originally conceived purpose of identifying strong binding interactions. Also reviewed are examples illustrating a trend towards increasing complexity in terms of network behaviour and reversible chemistry. Finally, new applications of dynamic combinatorial chemistry in self-assembly, transport and self-replication are discussed.

Graphical abstract: Dynamic combinatorial libraries: new opportunities in systems chemistry

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Publication details

The article was received on 09 Sep 2010, accepted on 04 Nov 2010 and first published on 29 Nov 2010


Article type: Feature Article
DOI: 10.1039/C0CC03759A
Citation: Chem. Commun., 2011,47, 847-858
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    Dynamic combinatorial libraries: new opportunities in systems chemistry

    R. A. R. Hunt and S. Otto, Chem. Commun., 2011, 47, 847
    DOI: 10.1039/C0CC03759A

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