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Issue 3, 2011
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Mechanistic insight into NOYORI asymmetric hydrogenations

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Abstract

The BINAP–Ru-catalyzed asymmetric hydrogenations have contributed fundamentally to “molecular catalyst chemistry”, as well as the “chemical industry”, in terms of the production of important chiral compounds such as pharmaceuticals, agrochemicals, flavors, fragrances, and health supplements since 1986 when the great breakthrough was made through an efficient asymmetric synthesis of tetrahydroisoquinolines. This highlight overviews mechanistic models proposed in the Noyori hydrogenation of olefins and ketones.

Graphical abstract: Mechanistic insight into NOYORI asymmetric hydrogenations

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Publication details

The article was received on 13 May 2010, accepted on 22 Jun 2010 and first published on 02 Aug 2010


Article type: Highlight
DOI: 10.1039/C0CC01390K
Citation: Chem. Commun., 2011,47, 842-846
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    Mechanistic insight into NOYORI asymmetric hydrogenations

    M. Kitamura and H. Nakatsuka, Chem. Commun., 2011, 47, 842
    DOI: 10.1039/C0CC01390K

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