Issue 3, 2011

Mechanistic insight into NOYORI asymmetric hydrogenations

Abstract

The BINAP–Ru-catalyzed asymmetric hydrogenations have contributed fundamentally to “molecular catalyst chemistry”, as well as the “chemical industry”, in terms of the production of important chiral compounds such as pharmaceuticals, agrochemicals, flavors, fragrances, and health supplements since 1986 when the great breakthrough was made through an efficient asymmetric synthesis of tetrahydroisoquinolines. This highlight overviews mechanistic models proposed in the Noyori hydrogenation of olefins and ketones.

Graphical abstract: Mechanistic insight into NOYORI asymmetric hydrogenations

Article information

Article type
Highlight
Submitted
13 May 2010
Accepted
22 Jun 2010
First published
02 Aug 2010

Chem. Commun., 2011,47, 842-846

Mechanistic insight into NOYORI asymmetric hydrogenations

M. Kitamura and H. Nakatsuka, Chem. Commun., 2011, 47, 842 DOI: 10.1039/C0CC01390K

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