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Issue 10, 2009
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Molecular dynamics simulation of F-actin reveals the role of cross-linkers in semi-flexible filament assembly

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Abstract

Hierarchically ordered protein networks are formed in solution by the self-assembly of F-actin, a semi-flexible biopolymer, in the presence of cross-linkers. We model the assembly of a 3D branching network of filament bundles using a coarse-grained molecular dynamics simulation, finding excellent agreement with experimental observations. We examine the role of cross-linker density on network morphology and filament curvature and observe a clear evolution from a loose single filament network to a network of bundles generated by cross-linker-induced branch points.

Graphical abstract: Molecular dynamics simulation of F-actin reveals the role of cross-linkers in semi-flexible filament assembly

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Publication details

The article was received on 14 Oct 2008, accepted on 07 Jan 2009 and first published on 26 Mar 2009


Article type: Paper
DOI: 10.1039/B817927A
Citation: Soft Matter, 2009,5, 2033-2036
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    Molecular dynamics simulation of F-actin reveals the role of cross-linkers in semi-flexible filament assembly

    L. T. Nguyen, W. Yang, Q. Wang and L. S. Hirst, Soft Matter, 2009, 5, 2033
    DOI: 10.1039/B817927A

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