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Issue 1, 2008
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Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns

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Abstract

We present a rapid and non-photolithographic approach to microfluidic pattern generation by leveraging the inherent shrinkage properties of biaxially oriented polystyrene thermoplastic sheets. This novel approach yields channels deep enough for mammalian cell assays, with demonstrated heights up to 80 µm. Moreover, we can consistently and easily achieve rounded channels, multi-height channels, and channels as thin as 65 µm in width. Finally, we demonstrate the utility of this simple microfabrication approach by fabricating a functional gradient generator. The whole process—from device design conception to working device—can be completed within minutes.

Graphical abstract: Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns

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Publication details

The article was received on 31 Jul 2007, accepted on 02 Nov 2007 and first published on 20 Nov 2007


Article type: Technical Note
DOI: 10.1039/B711622E
Citation: Lab Chip, 2008,8, 170-172
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    Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns

    A. Grimes, D. N. Breslauer, M. Long, J. Pegan, L. P. Lee and M. Khine, Lab Chip, 2008, 8, 170
    DOI: 10.1039/B711622E

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