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Issue 3, 2007
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Synthetic metallomolecules as agents for the control of DNA structure

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Abstract

This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes, metallohelicates and platinum complexes such as cis-platin are discussed alongside the techniques of NMR, X-ray crystallography, gel electrophoresis, circular dichroism, linear dichroism and molecular dynamics. The review will be of interest to people interested in both DNA structure and roles of metallomolecules in biological systems.

Graphical abstract: Synthetic metallomolecules as agents for the control of DNA structure

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Publication details

The article was received on 04 Jul 2006, accepted on 13 Sep 2006 and first published on 17 Oct 2006


Article type: Tutorial Review
DOI: 10.1039/B609495C
Citation: Chem. Soc. Rev., 2007,36, 471-483
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    Synthetic metallomolecules as agents for the control of DNA structure

    A. D. Richards and A. Rodger, Chem. Soc. Rev., 2007, 36, 471
    DOI: 10.1039/B609495C

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