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Issue 3, 2007
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Chemo-differentiating ABB′ multicomponent reactions. Privileged building blocks

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Abstract

Multicomponent reactions (MCRs) designated as ABB′ are defined as those reactions that introduce into the final product one molecule of component A and two molecules of component B in a chemo-differentiating manner. This ability to discriminate the incorporation of component B ensures that these processes maintain the advantages of using multicomponent reactions in diversity-oriented molecular construction. Furthermore, they benefit from the fact that only two reagents need to be mixed together. Component B can be therefore considered to be a privileged building block, and the reactions in which it participates, chemo-differentiating multicomponent reactions. Among the reduced set of compounds capable of acting as such building blocks, we discuss the use of ketenes, terminal conjugated alkynoates, enolisable carbonyl compounds, cyclic enol ethers and cyclic enamines.

Graphical abstract: Chemo-differentiating ABB′ multicomponent reactions. Privileged building blocks

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Publication details

The article was received on 11 Jul 2006, accepted on 14 Sep 2006 and first published on 16 Oct 2006


Article type: Tutorial Review
DOI: 10.1039/B608164A
Citation: Chem. Soc. Rev., 2007,36, 484-491
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    Chemo-differentiating ABB′ multicomponent reactions. Privileged building blocks

    D. Tejedor and F. García-Tellado, Chem. Soc. Rev., 2007, 36, 484
    DOI: 10.1039/B608164A

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