A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.
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Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe
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a
School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: j.tucker@bham.ac.uk ;
Fax: +44 (0)12 1414 4403 ;
Tel: +44 (0)12 1414 4422
E-mail: j.tucker@bham.ac.uk ;
Fax: +44 (0)12 1414 4403 ;
Tel: +44 (0)12 1414 4422
b
Laboratoire de Chimie Organique et Organométallique, Université Bordeaux 1, 351 Crs Libération, Talence, France
E-mail: d.bassani@lcoo.u-bordeaux1.fr ;
Fax: 33(0) 540 00 6158 ;
Tel: 33(0) 540 00 2827
E-mail: d.bassani@lcoo.u-bordeaux1.fr ;
Fax: 33(0) 540 00 6158 ;
Tel: 33(0) 540 00 2827
c
School of Chemistry and Chemical Engineering, Queen's University Belfast (QUB), Stranmillis Road, Belfast, UK
E-mail: j.vyle@qub.ac.uk ;
Fax: +44 (0)28 9097 6524 ;
Tel: +44 (0)28 9097 5485
E-mail: j.vyle@qub.ac.uk ;
Fax: +44 (0)28 9097 6524 ;
Tel: +44 (0)28 9097 5485
d
School of Biological and Chemical Sciences, Malet Street, Bloomsbury, UK
Chem. Commun., 2006, 5003-5005
DOI: 10.1039/B611650G
Received 14 Aug 2006, Accepted 23 Oct 2006
First published online 06 Nov 2006
Chemical Communications
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