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Issue 19, 2002
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Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry

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Abstract

Rapid and simple chiral analysis of thalidomide solutions is demonstrated by using electrospray ionization tandem mass spectrometry and analysis of cluster ion dissociation by the kinetic method. Average deviations of 1% between the actual and experimental enantiomeric compositions are observed.

Graphical abstract: Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry

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Publication details

The article was received on 09 May 2002, accepted on 22 Aug 2002 and first published on 09 Sep 2002


Article type: Communication
DOI: 10.1039/B204421H
Citation: Chem. Commun., 2002,0, 2242-2243
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    Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry

    D. V. Augusti, R. Augusti, F. Carazza and R. G. Cooks, Chem. Commun., 2002, 0, 2242
    DOI: 10.1039/B204421H

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