Methyltrichlorosilane or tetrachlorosilane in trifluoroacetic acid, in the presence of diphenylsulphoxide, is found to cleave various S-protecting groups of cysteine to form cystine directly by the reduction–oxidation reaction; this new disulphide bond forming reaction is successfully applied to the syntheses of oxytocin and human brain natriuretic peptide.
K. Akaji, T. Tatsumi, M. Yoshida, T. Kimura, Y. Fujiwara and Y. Kiso, J. Chem. Soc., Chem. Commun., 1991, 167 DOI: 10.1039/C39910000167
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