The preparation and characterisation of cis-[PtCl2(NH3)(misonidazole)] and cis-[PtCl2(NH3)(metronidazole)] is reported; these complexes bind to DNA and radiosensitize more efficiently than their analogues containing two nitroimidazole groups, and the results confirm the possibility of targeting radiosensitizing ligands to DNA by complexation with platinum.
N. Farrell and K. A. Skov, J. Chem. Soc., Chem. Commun., 1987, 1043 DOI: 10.1039/C39870001043
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