A unified synthesis of N-Me-carbazoquinocin A, B and D–F is reported. An acid-catalyzed intramolecular benzannulation of indole-appended Z-enoate propargylic alcohols, is employed for the construction of the carbazole framework.
Novel prolinamides containing a phenol OH as the H-bond donor group have been reported as conformationally flexible organocatalysts.
Nucleophilic opening of aryloxiranes with benzylpiperidine and subsequent rearrangement under Mitsunobu conditions led regioselectively to α-aryl-β-piperidinoalcohols and -amines. Amino-ifenprodil and indazole bioisosteres show high GluN2B affinity.
A unified total synthesis of eight 2,4-disubstituted furan-derived natural products has been achieved through Bi(III)-catalyzed cascade cycloisomerization of α-hydroxyoxetanyl ketones and hydrogen atom transfer-mediated oxidation of primary alcohols as pivotal transformations.
The mechanism of substrate selective inhibition suggests inter-monomer communication within the allosteric ALOX15 dimer complex.