The pan-cancer analysis of LRG1 and its potential role in kidney renal clear cell carcinoma

Ziwen Lei, Shiyu Song, Yizhuo Geng, Bian Liu, Yongzheng Li, Huan Min, Saiyang Zhang and Yingqiu Qi

RSC Med. Chem., 2025, 16, 1781
DOI: 10.1039/D4MD00940A

Bioorthogonal site-selective conjugation of fluorescent dyes to antibodies: method and potential applications

Philipp Grossenbacher, Maria C. Essers, Joël Moser, Simon A. Singer, Stephanie Häusler, Bruno Stieger, Jean-Sébastien Rougier and Martin Lochner

RSC Adv., 2022, 12, 28306
DOI: 10.1039/D2RA05580E

The use of bromopyridazinedione derivatives in chemical biology

Calise Bahou and Vijay Chudasama

Org. Biomol. Chem., 2022, 20, 5879
DOI: 10.1039/D2OB00310D

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Fabien Thoreau, Léa N. C. Rochet, James R. Baker and Vijay Chudasama

Chem. Sci., 2023, 14, 3752
DOI: 10.1039/D2SC06318B

Non-internalising antibody–drug conjugates

Nicola Ashman, Jonathan D. Bargh and David R. Spring

Chem. Soc. Rev., 2022, 51, 9182
DOI: 10.1039/D2CS00446A

Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones

Calise Bahou, Richard J. Spears, Angela M. Ramírez Rosales, Léa N. C. Rochet, Lydia J. Barber, Ksenia S. Stankevich, Juliana F. Miranda, Tobias C. Butcher, Adam M. Kerrigan, Vlado K. Lazarov, William Grey, Vijay Chudasama and Christopher D. Spicer

Biomacromolecules, 2023, 24, 4646
DOI: 10.1021/acs.biomac.3c00290

Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification

Lucile Grzesiak, Ana Amaya-Garrido, Guylène Feuillet, Nicole Malet, Audrey Swiader, Marie-Kerguelen Sarthou, Amandine Wahart, Damien Ramel, Stéphanie Gayral, Joost Peter Schanstra, Julie Klein and Muriel Laffargue

IJMS, 2023, 24, 16537
DOI: 10.3390/ijms242216537

Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth

Meng Gao, Hang Dong, Siyi Jiang, Fangping Chen, Yunfeng Fu and Yanwei Luo

Oncogenesis, 2024, 13
DOI: 10.1038/s41389-024-00522-5

Application of LRG mechanism in normal pressure hydrocephalus

Luyao Ma, Wencai Wang, Yongqiang Zhao, Menghao Liu, Wei Ye and Xianfeng Li

Heliyon, 2024, 10, e23940
DOI: 10.1016/j.heliyon.2023.e23940

Diverse drug delivery systems for the enhancement of cancer immunotherapy: an overview

Xu Liu, Yang Cheng, Yao Mu, Zhaohan Zhang, Dan Tian, Yunpeng Liu, Xuejun Hu and Ti Wen

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1328145

Revealing the multiple faces of LRG1: gene expression, structure, function, and therapeutic potential

Ding Wang, Di Di, Bo Jiang, Yunlong Wang, Zhenqi Jiang, Yuchen Jing, Huizhe Wu and Shijie Xin

Journal of Advanced Research, 2025
DOI: 10.1016/j.jare.2025.05.024

LRG1 Is Involved in the Progression of Ovarian Cancer via Modulating FAK/AKT Signaling Pathway

Dongling Wu, Weiwei Xie, Xin Chen and Huizhen Sun

Front. Biosci. (Landmark Ed), 2023, 28
DOI: 10.31083/j.fbl2805101

Contemporary Approaches to Immunotherapy of Solid Tumors

Alla V. Kuznetsova, Xenia A. Glukhova, Olga P. Popova, Igor P. Beletsky and Alexey A. Ivanov

Cancers, 2024, 16, 2270
DOI: 10.3390/cancers16122270

LRG1: an emerging player in disease pathogenesis

Carlotta Camilli, Alexandra E. Hoeh, Giulia De Rossi, Stephen E. Moss and John Greenwood

J Biomed Sci, 2022, 29
DOI: 10.1186/s12929-022-00790-6

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway

Athina Dritsoula, Laura Dowsett, Camilla Pilotti, Marie N. O’Connor, Stephen E. Moss and John Greenwood

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-08516-2

The role of leucine-rich alpha-2-glycoprotein-1 in proliferation, migration, and invasion of tumors

Meng Lin, Jinmeng Liu, Fengping Zhang, Gaoxiu Qi, Shuqi Tao, Wenyuan Fan, Min Chen, Kang Ding and Fenghua Zhou

J Cancer Res Clin Oncol, 2022, 148, 283
DOI: 10.1007/s00432-021-03876-0

LRG1 Alters Pericyte Phenotype and Compromises Vascular Maturation

Alexandra E. Hoeh, Jui-Hsien Chang, Ronja S. Mueller, Mark Basche, Alessandro Fantin, Anastasios Sepetis, Giulia De Rossi, Athina Dritsoula, Robin R. Ali, Patric Turowski, Stephen E. Moss and John Greenwood

Cells, 2025, 14, 593
DOI: 10.3390/cells14080593

High serum levels of leucine-rich α-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer

Andy Göbel, Tilman D. Rachner, Oliver Hoffmann, Daniel Martin Klotz, Sabine Kasimir-Bauer, Rainer Kimmig, Lorenz C. Hofbauer and Ann-Kathrin Bittner

Arch Gynecol Obstet, 2024, 309, 2789
DOI: 10.1007/s00404-024-07434-0

Unlocking the potential of bispecific ADCs for targeted cancer therapy

Hongye Zeng, Wenjing Ning, Xue Liu, Wenxin Luo and Ningshao Xia

Front. Med., 2024, 18, 597
DOI: 10.1007/s11684-024-1072-8

LncRNA AGAP2-AS1 interacts with IGF2BP2 to promote bladder cancer progression via regulating LRG1 mRNA stability

Xu Zhao, Jinbo Chen, Chunyu Zhang, Guoou Xie, Belaydi Othmane, Xiaogen Kuang and Bolong Liu

Cellular Signalling, 2023, 111, 110839
DOI: 10.1016/j.cellsig.2023.110839

Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence

Esmee P. Hoefsmit, Franziska Völlmy, Elisa A. Rozeman, Irene L.M. Reijers, Judith M. Versluis, Liesbeth Hoekman, Alexander C.J. van Akkooi, Georgina V. Long, Dirk Schadendorf, Reinhard Dummer, Maarten Altelaar and Christian U. Blank

Cancer Research Communications, 2023, 3, 672
DOI: 10.1158/2767-9764.CRC-23-0015

The Evolving Landscape of Antibody–Drug Conjugates: In Depth Analysis of Recent Research Progress

Janet M. Sasso, Rumiana Tenchov, Robert Bird, Kavita A. Iyer, Krittika Ralhan, Yacidzohara Rodriguez and Qiongqiong Angela Zhou

Bioconjugate Chem., 2023, 34, 1951
DOI: 10.1021/acs.bioconjchem.3c00374