Controlling the optical and catalytic properties of artificial metalloenzyme photocatalysts using chemogenetic engineering

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Chem. Sci., 2022, 13, 1459
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Application of engineered myoglobins for biosynthesis of clofazimine by integration with chemical synthesis

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Org. Biomol. Chem., 2023, 21, 9603
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Corrole–protein interactions in H-NOX and HasA

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RSC Chem. Biol., 2022, 3, 571
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Rational design and applications of artificial metalloenzymes based on neuroglobin

Li-Juan Sun and Ying-Wu Lin

Dalton Trans., 2026, 55, 4763
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A polyacrylamide gel containing an engineered hexameric hemoprotein as a cross-linking unit toward redox-responsive materials

Kazuki Kageyama, Koji Oohora and Takashi Hayashi

RSC Adv., 2023, 13, 34610
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Focusing on a nickel hydrocorphinoid in a protein matrix: methane generation by methyl-coenzyme M reductase with F430 cofactor and its models

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Chem. Soc. Rev., 2022, 51, 1629
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3,6,13,16-Tetraalkylporphycenes: synthesis and exploration of the effect of alkyl groups on the structure, photophysical properties, and basicity

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Biohybrid materials comprising an artificial peroxidase and differently shaped gold nanoparticles

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An artificial metalloenzyme that can oxidize water photocatalytically: design, synthesis, and characterization

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Chem. Sci., 2024, 15, 3596
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Engineered myoglobin as a catalyst for atom transfer radical cyclisation

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Chem. Commun., 2022, 58, 10989
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Nanosized porous artificial enzyme as a pH-sensitive doxorubicin delivery system for joint enzymatic and chemotherapy towards tumor treatment

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New J. Chem., 2022, 46, 14565
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Protein‐Porphyrin Complex Photosensitizers for Anticancer and Antimicrobial Photodynamic Therapies

Taiga Yamada and Teruyuki Komatsu

ChemMedChem, 2023, 18
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Multiple catalytic functions of an engineered double mutant of myoglobin with a potential metal-binding site

Ai-Qun Pan, Xi-Chun Liu, Lu Yu, Shuai Tang, Shu-Qin Gao and Ying-Wu Lin

Journal of Inorganic Biochemistry, 2025, 271, 112976
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Directed evolution enhances the peroxidation activity of myoglobin reconstituted with an iron corrole complex

Koki Takeuchi, Shunsuke Kato, Rina Ueshima and Takashi Hayashi

Bulletin of the Chemical Society of Japan, 2026, 99
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Functionalised Cofactor Mimics for Interactome Discovery and Beyond

Isabel V. L. Wilkinson, Martin Pfanzelt and Stephan A. Sieber

Angew Chem Int Ed, 2022, 61
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Regulating the Heme Active Site by Covalent Modifications: Two Case Studies of Myoglobin

Ze‐Yuan Chen, Hong Yuan, Huamin Wang, Li‐Juan Sun, Lu Yu, Shu‐Qin Gao, Xiangshi Tan and Ying‐Wu Lin

ChemBioChem, 2024, 25
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An engineered thermally tolerant apo-cytochrome scaffold for metal-less incorporation of heme derivative

Sami Ben Aoun, Sheikh Muhammad Ibrahim and Kshatresh Dutta Dubey

PLoS ONE, 2023, 18, e0293972
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Kinetic and structural analysis of redox-reversible artificial imine reductases

Alex H. Miller, Ingrid B.S. Martins, Elena V. Blagova, Keith S. Wilson and Anne-K. Duhme-Klair

Journal of Inorganic Biochemistry, 2024, 260, 112691
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Metabolic engineering of yeast to efficiently synthesize heme and hemoproteins: recent advance and prospects

Haibo Yu, Yunpeng Wang, Yijie Wang, Yueheng Niu, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du and Xinrui Zhao

FEMS Yeast Research, 2025, 25
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Natural Enzymes and Nanozymes: A Comparative Review of Structure, Mechanism and Kinetics

Manoharmayum Vishwanath Sharma, A. Ibeyaima, Bhaben Sharmah, Nazim Uddin Afzal and Prasenjit Manna

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Rational Design of an Artificial Metalloenzyme by Constructing a Metal-Binding Site Close to the Heme Cofactor in Myoglobin

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Inorg. Chem., 2024, 63, 18531
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Nitrene transfers mediated by natural and artificial iron enzymes

Guillaume Coin and Jean-Marc Latour

Journal of Inorganic Biochemistry, 2021, 225, 111613
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Evolutionary Engineering of a Cp*Rh(III) Complex-Linked Artificial Metalloenzyme with a Chimeric β-Barrel Protein Scaffold

Shunsuke Kato, Akira Onoda, Ulrich Schwaneberg and Takashi Hayashi

J. Am. Chem. Soc., 2023, 145, 8285
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Metal–ligand bonding and noncovalent interactions of mutated myoglobin proteins: a quantum mechanical study

Juliana J. Antonio and Elfi Kraka

Pure and Applied Chemistry, 2025, 97, 1435
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Phenoxazinone Synthase-like Activity of Rationally Designed Heme Enzymes Based on Myoglobin

Li-Juan Sun, Hong Yuan, Jia-Kun Xu, Jie Luo, Jia-Jia Lang, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin

Biochemistry, 2023, 62, 369
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Systematic engineering of Saccharomyces cerevisiae for efficient synthesis of hemoglobins and myoglobins

Jike Xue, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Miao Wang and Xinrui Zhao

Bioresource Technology, 2023, 370, 128556
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Zinc‐Substituted Hemoglobin–Albumin Cluster as a Porphyrin‐Carrier for Enhanced Photodynamic Therapy

Taiga Yamada, Maho Katsumi, Kota Ishii and Teruyuki Komatsu

Chemistry An Asian Journal, 2024, 19
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Reconstitution of Myoglobin with Iron Porphycene Generates an Artificial Aldoxime Dehydratase with Expanded Catalytic Activities

Shunsuke Kato, Miteki Abe, Harald Gröger and Takashi Hayashi

ACS Catal., 2024, 14, 13081
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Engineered hemoproteins containing non-canonical cofactors toward artificial metalloenzymes

Koji Oohora

Journal of Inorganic Biochemistry, 2025, 273, 113026
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Metalloporphycene is an Attractive Cofactor for Hemoproteins

Takashi Hayashi

Bulletin of the Chemical Society of Japan, 2023, 96, 1331
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O2 Carrier Myoglobin Also Exhibits β-Lactamase Activity That Is Regulated by the Heme Coordination State

Shuai Tang, Ai-Qun Pan, Xiao-Juan Wang, Shu-Qin Gao, Xiang-Shi Tan and Ying-Wu Lin

Molecules, 2022, 27, 8478
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Artificial Biocatalysis: Quo Vadis?

Aaron A. Ingram and Keiko Oike

ChemCatChem, 2024, 16
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Switching Type I/Type II Reactions by Turning a Photoredox Catalyst into a Photo-Driven Artificial Metalloenzyme

Yasunori Okamoto, Takuya Mabuchi, Keita Nakane, Akiko Ueno and Shinichi Sato

ACS Catal., 2023, 13, 4134
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Incorporation of metal-chelating unnatural amino acids into halotag for allylic deamination

Alina Stein, Alexandria Deliz Liang, Reyhan Sahin and Thomas R. Ward

Journal of Organometallic Chemistry, 2022, 962, 122272
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Functional metalloenzymes based on myoglobin and neuroglobin that exploit covalent interactions

Ying-Wu Lin

Journal of Inorganic Biochemistry, 2024, 257, 112595
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Reactivity of Myoglobin Reconstituted with Cobalt Corrole toward Hydrogen Peroxide

Koji Oohora, Hirotaka Tomoda and Takashi Hayashi

IJMS, 2022, 23, 4829
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Transport of Zinc‐Phthalocyanine to Cancer Cells Using Myoglobin−Albumin Fusion Protein for Photodynamic Therapy

Taiga Yamada, Mizuki Funamoto, Ryoya Takada, Yoshitsugu Morita and Teruyuki Komatsu

ChemBioChem, 2024, 25
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Picket-fence ruthenium(II) phthalocyaninates bearing (1R,2S,5R)-menthoxy groups as prototype of chiral catalysts

Andrey P. Kroitor, Anna A. Sinelshchikova, Mikhail S. Grigoriev, Gayane A. Kirakosyan, Alexander G. Martynov, Yulia G. Gorbunova and Alexander B. Sorokin

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Funktionalisierte Cofaktor‐Analoga für die Erforschung von Interaktomen und darüber hinaus

Isabel V. L. Wilkinson, Martin Pfanzelt and Stephan A. Sieber

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Reactivity of nitrogen species with inorganic and organic compounds in water

Virender K. Sharma, Kyriakos Manoli and Xingmao Ma

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Engineered Hemoproteins toward Artificial Metalloenzymes and Metalloprotein-based Nanomaterials

Koji Oohora

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Zinc Substituted Myoglobin−Albumin Fusion Protein: A Photosensitizer for Cancer Therapy

Taiga Yamada, Yoshitsugu Morita, Ryoya Takada, Mizuki Funamoto, Wataru Okamoto, Mitsutomo Kohno and Teruyuki Komatsu

Chemistry A European J, 2023, 29
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Artificial Small Molecules as Cofactors and Biomacromolecular Building Blocks in Synthetic Biology: Design, Synthesis, Applications, and Challenges

Fenghua Liu, Lingling He, Sheng Dong, Jinsong Xuan, Qiu Cui and Yingang Feng

Molecules, 2023, 28, 5850
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Supramolecular assembling systems of hemoproteins using chemical modifications

Koji Oohora

J Incl Phenom Macrocycl Chem, 2023, 103, 97
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Diversifying the functions of heme proteins with non-porphyrin cofactors

Christopher M. Lemon

Journal of Inorganic Biochemistry, 2023, 246, 112282
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A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis

Akiko Ueno, Fumiko Takida, Tomoki Kita, Takuro Ishii, Tomoki Himiyama, Takuya Mabuchi and Yasunori Okamoto

Nat Commun, 2025, 16
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