Noncancerous disease-targeting AIEgens

Yanhong Duo, Guanghong Luo, Wentao Zhang, Renzhi Wang, Gary Guishan Xiao, Zihuang Li, Xianming Li, Meili Chen, Juyoung Yoon and Ben Zhong Tang

Chem. Soc. Rev., 2023, 52, 1024
DOI: 10.1039/D2CS00610C

Construction of antibacterial bone implants and their application in bone regeneration

Pei Feng, Ruizhong He, Yulong Gu, Feng Yang, Hao Pan and Cijun Shuai

Mater. Horiz., 2024, 11, 590
DOI: 10.1039/D3MH01298K

Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent vancomycin-based probe

Richa Sharma, Harinee Rajagopalan, Maxime Klausen, Mani Vimalin Jeyalatha, Muhammed Üçüncü, Seshasailam Venkateswaran, Appakkudal R. Anand and Mark Bradley

Sens. Diagn., 2022, 1, 1014
DOI: 10.1039/D2SD00061J

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Zhijun Zhang, Miaomiao Kang, Hui Tan, Nan Song, Meng Li, Peihong Xiao, Dingyuan Yan, Liping Zhang, Dong Wang and Ben Zhong Tang

Chem. Soc. Rev., 2022, 51, 1983
DOI: 10.1039/D1CS01138C

Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria

Jianye Gong, Lingxiu Liu, Chunbin Li, Yumao He, Jia Yu, Ying Zhang, Lina Feng, Guoyu Jiang, Jianguo Wang and Ben Zhong Tang

Chem. Sci., 2023, 14, 4863
DOI: 10.1039/D3SC00980G

Antibacterial AIE polycarbonates endowed with selective imaging capabilities by adjusting the electrostaticity of the mixed-charge backbone

Junyong Zhang, Wencheng Liang, Lianlei Wen, Zhimin Lu, Yan Xiao and Meidong Lang

Biomater. Sci., 2021, 9, 5293
DOI: 10.1039/D1BM00894C

Activatable peptide–AIEgen conjugates for cancer imaging

Sisi Zhou, Xianbao Sun and Gaolin Liang

Chem. Sci., 2025, 16, 5369
DOI: 10.1039/D4SC08633C

Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy

Duoyang Fan, Xiaohui Liu, Yueming Ren, Ziheng Luo, Yanbing Li, Jie Dong, Seraphine V. Wegner, Fei Chen and Wenbin Zeng

Acta Pharmaceutica Sinica B, 2024, 14, 1759
DOI: 10.1016/j.apsb.2023.12.016

Photosensitizers with aggregation-induced far-red/near-infrared emission for versatile visualization and broad-spectrum photodynamic killing of pathogenic microbes

Jiabao Luo, Ping Yang, Jingxi Cheng, Jiaqi Fan, Weiying Zhou, Yaru Lu, XiaoBao Xie, Wenbo Wu and Xinguo Zhang

Journal of Colloid and Interface Science, 2023, 634, 664
DOI: 10.1016/j.jcis.2022.12.062

Nanomaterials-based fluorescent assays for pathogenic bacteria in food-related matrices

Guojian Wu, Huimin Qiu, Xin Liu, Pengjie Luo, Yongning Wu and Yizhong Shen

Trends in Food Science & Technology, 2023, 142, 104214
DOI: 10.1016/j.tifs.2023.104214

Restricting Bond Rotations by Ring Fusion: A Novel Molecular Design Strategy to Improve Photodynamic Antibacterial Efficacy of AIE Photosensitizers

Haixing Shi, Xiaohong Pan, Yaqi Wang, Huanhuan Wang, Wenzhen Liu, Le Wang and Zhuo Chen

ACS Appl. Mater. Interfaces, 2022, 14, 17055
DOI: 10.1021/acsami.1c24329

Engineering molecular theranostic probes for antibacterial therapy

Xiaoyu Wang, Jiankang Gong, Jiaxuan Wang, Fan Zhang, Zhiqiang Mao and Zhihong Liu

TrAC Trends in Analytical Chemistry, 2023, 167, 117232
DOI: 10.1016/j.trac.2023.117232

Aggregation-induced emission shining in the biomedical field: From bench to bedside

Yishen Liu, Qingrong Chen, Yidan Sun, Luojia Chen, Yuncong Yuan and Meijia Gu

Engineered Regeneration, 2021, 2, 206
DOI: 10.1016/j.engreg.2021.11.001

Spatial Order of Functional Modules Enabling Diverse Intracellular Performance of Fluorescent Probes

Chong Duan, Jing‐Jing Hu, Rui Liu, Jun Dai, Mojie Duan, Lizhen Yuan, Fan Xia and Xiaoding Lou

Angew Chem Int Ed, 2021, 60, 18280
DOI: 10.1002/anie.202106195

Peptide-photosensitizer conjugates: From molecular design to function and antibacterial applications

Guanghui Zhao, Peng Tan, Qi Tang, Chenlong Zhou, Shuaikang Yang, Yucheng Zhang, Zhenduo Chen, Feng Li and Xi Ma

Chemical Engineering Journal, 2025, 514, 162723
DOI: 10.1016/j.cej.2025.162723

Nanostructured organic photosensitizer aggregates in disease phototheranostics

Maochao Zheng, Qianqian Yang, Chao Lu, Xiaolei Wu, Wei Yan and Daojun Liu

Drug Discovery Today, 2023, 28, 103598
DOI: 10.1016/j.drudis.2023.103598

Recent Advances in Aggregation-Induced Emission Bioconjugates

Guiquan Zhang, Daming Zhou, Rong Hu, Anjun Qin and Ben Zhong Tang

Bioconjugate Chem., 2025, 36, 609
DOI: 10.1021/acs.bioconjchem.5c00036

Functional insights to the development of bioactive material for combating bacterial infections

Duoyang Fan, Xiaohui Liu, Yueming Ren, Shuaige Bai, Yanbing Li, Ziheng Luo, Jie Dong, Fei Chen and Wenbin Zeng

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1186637

Cascade-Activated AIEgen-Peptide Probe for Noninvasively Monitoring Chymotrypsin-like Activity of Proteasomes in Cancer Cells

Qishu Jiao, Yaxin Zheng, Shicheng Pei, Xuan Luo, Xiaoxing Wu, Keming Xu and Wenying Zhong

Anal. Chem., 2023, 95, 9097
DOI: 10.1021/acs.analchem.3c01589

A narrative review for antibacterials design and modification targeting outer membrane against Gram-negative bacteria

Zhenlin Lai, Jiayi Xu, Yuxing Zhao, Juan Wang, Dongyang Ye, Haijin Liu, Xinglong Wang, Zengqi Yang and Leina Dou

Animals and Zoonoses, 2026
DOI: 10.1016/j.azn.2026.01.007

Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections

Tan Phuoc Ton, Richard Bright, Vi Khanh Truong and Krasimir Vasilev

Small Science, 2025, 5
DOI: 10.1002/smsc.202500138

Intrinsic Fluorescence in Peptide Amphiphile Micelles with Protein-Inspired Phosphate Sensing

Whitney C. Fowler

Biomacromolecules, 2022, 23, 4804
DOI: 10.1021/acs.biomac.2c00960

Sensitive detection of S. Aureus using aptamer- and vancomycin -copper nanoclusters as dual recognition strategy

Azam Bagheri Pebdeni, Maryam Mousavizadegan and Morteza Hosseini

Food Chemistry, 2021, 361, 130137
DOI: 10.1016/j.foodchem.2021.130137

Fluorescent copper clusters with aggregation-induced emission enhancement effect for detecting Escherichia coli and Salmonella typhimurium

Li Fu, Fangzhou Lv, Kaixin Liu, Ruobo Chen, Hongxuan Zhang, Huihui Su, Yi Fan and Li Jia

Microchemical Journal, 2025, 208, 112574
DOI: 10.1016/j.microc.2024.112574

Spatial Order of Functional Modules Enabling Diverse Intracellular Performance of Fluorescent Probes

Chong Duan, Jing‐Jing Hu, Rui Liu, Jun Dai, Mojie Duan, Lizhen Yuan, Fan Xia and Xiaoding Lou

Angewandte Chemie, 2021, 133, 18428
DOI: 10.1002/ange.202106195

Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies

Tracey Luu, Wenyi Li, Neil M. O'Brien‐Simpson and Yuning Hong

Chemistry An Asian Journal, 2021, 16, 1027
DOI: 10.1002/asia.202100102

Theranostic applications of biomolecule‐responsive aggregation‐induced emission luminogens

Yanan Liao, Zhen Peng, Xiaolin Liu, Yubing Hu and Jing Zhang

Interdisciplinary Medicine, 2023, 1
DOI: 10.1002/INMD.20230024

An LPS-targeted fluorescent probe for dynamic super-resolution imaging of Gram-negative bacterial outer membranes

Yi Tao, Jie Pan, Wenting Yin, Qinglong Qiao and Zhaochao Xu

Chinese Chemical Letters, 2026, 112611
DOI: 10.1016/j.cclet.2026.112611

Detection and Treatment with Peptide Power: A New Weapon Against Bacterial Biofilms

Ao Yang, Yalin Bai, Yuntao Zhang, Runsha Xiao, Hanli Zhang, Fei Chen and Wenbin Zeng

ACS Biomater. Sci. Eng., 2025, 11, 806
DOI: 10.1021/acsbiomaterials.4c02199

Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

Luojia Chen, Xingran Wang, Yuncong Yuan, Rui Hu, Qingrong Chen, Lijun Zhu, Meijia Gu and Chao Shen

Engineered Regeneration, 2022, 3, 59
DOI: 10.1016/j.engreg.2022.01.005

Polydopamine-polyethylenimine nanoparticles with photothermal-antimicrobial synergy for enhanced wound healing

Hanchun Shen, Pei Xie, Renjie Yi, Jiamei Zhou, Shenggang Huang, Liang Zhang, Xiaojuan Huang, Jiulong Zhao, Shige Wang and Chunping Zhu

Journal of Colloid and Interface Science, 2025, 694, 137713
DOI: 10.1016/j.jcis.2025.137713

Polymyxin B delivery systems: smart solutions for improved antibacterial activity and reduced toxicity

Ying Cheng, Mingdong Yang, Bin Lin, Wei Hu, Yangmin Hu, Haibin Dai and Junjun Xu

Journal of Drug Targeting, 2025, 33, 1757
DOI: 10.1080/1061186X.2025.2527859

Recent Progress in Identifying Bacteria with Fluorescent Probes

Yuefeng Ji, Guanhao Li, Juan Wang, Chunxiang Piao and Xin Zhou

Molecules, 2022, 27, 6440
DOI: 10.3390/molecules27196440

Near-Infrared-Emissive AIE Bioconjugates: Recent Advances and Perspectives

Wenshuai Luo, Yonghong Tan, Yixiong Gui, Dingyuan Yan, Dong Wang and Ben Zhong Tang

Molecules, 2022, 27, 3914
DOI: 10.3390/molecules27123914

Surface-enhanced Raman scattering biosensor-based sandwich-type for facile and sensitive detection of Staphylococcus aureus

Wenya Wei, Suleiman A. Haruna, Yumeng Zhao, Huanhuan Li and Quansheng Chen

Sensors and Actuators B: Chemical, 2022, 364, 131929
DOI: 10.1016/j.snb.2022.131929

Environmental community transcriptomics: strategies and struggles

Jeanet Mante, Kyra E Groover and Randi M Pullen

Briefings in Functional Genomics, 2025, 24
DOI: 10.1093/bfgp/elae033

Breaching Bacterial Biofilm Barriers: Efficient Combinatorial Theranostics for Multidrug-Resistant Bacterial Biofilms with a Novel Penetration-Enhanced AIEgen Probe

Xiaohui Liu, Duoyang Fan, Xueping Feng, Yanjun Zheng, Seraphine V. Wegner, Meihui Liu, Fei Chen and Wenbin Zeng

ACS Appl. Mater. Interfaces, 2022, 14, 41671
DOI: 10.1021/acsami.2c07378

Aggregation-induced emission of TTCPy-3: A novel approach for eradicating Nocardia seriolae infections in aquatic fishes

Zhigang Liu, Junling Zhang, Xiaona Ma, Miao Wang, Lijin Jiang, Meiyan Zhang, Maixin Lu, Ouqin Chang, Jianmeng Cao, Xiaoli Ke and Mengmeng Yi

Biosensors and Bioelectronics, 2024, 254, 116208
DOI: 10.1016/j.bios.2024.116208

Advanced strategies for the diagnosis, treatment, and vaccination of monkeypox

Wei Wang, Qiuxia Gao, Yongchao Li, Hui Guo, Judun Zheng, Yu Fu and Yuhui Liao

J Nanobiotechnol, 2026
DOI: 10.1186/s12951-025-03876-z

Near-infrared emissive AIE nanoparticles for biomedical applications: From the perspective of different nanocarriers

Dingyuan Yan, Yi Qin, Saisai Yan, Panpan Sun, Yuanwei Wang, Dong Wang and Ben Zhong Tang

Particuology, 2023, 74, 103
DOI: 10.1016/j.partic.2022.06.001

Photostable Aggregation-Induced Emission Photosensitizer Nanoparticle/Hyaluronic Acid Hydrogel for Efficient Photodynamic Tooth Bleaching

Jing Gao, Junhua Wang, Xin Yue, Yuanzhu Zhou, Minghui Wang, Yiqing Sun, Qianyu Zhang, Zhiyuan Gao, Guo-Qiang Zhang, Jing Shen and Dan Ding

ACS Appl. Nano Mater., 2022, 5, 5944
DOI: 10.1021/acsanm.1c03912

Nanomaterial-based strategies in antimicrobial applications: Progress and perspectives

Yi Zhao, Long Chen, Yanan Wang, Xinyu Song, Keyang Li, Xuefeng Yan, Liangmin Yu and Zhiyu He

Nano Res., 2021, 14, 4417
DOI: 10.1007/s12274-021-3417-4

Strategies of Detecting Bacteria Using Fluorescence-Based Dyes

Shin A Yoon, Sun Young Park, Yujin Cha, Lavanya Gopala and Min Hee Lee

Front. Chem., 2021, 9
DOI: 10.3389/fchem.2021.743923

AIEgen-Conjugated Phase-Separating Peptides Illuminate Intracellular RNA through Coacervation-Induced Emission

Shi Yang, Han Yu, Xiuli Xu, Ting Yang, Yue Wei, Rui Zan, Xiaonong Zhang, Qingming Ma, Ho Cheung Shum and Yang Song

ACS Nano, 2023, 17, 8195
DOI: 10.1021/acsnano.2c12072

Recent advances of fluorescent sensors for bacteria detection-A review

Jialin Zhang, Ming Zhou, Xin Li, Yaqi Fan, Jinhui Li, Kangqiang Lu, Herui Wen and Jiali Ren

Talanta, 2023, 254, 124133
DOI: 10.1016/j.talanta.2022.124133

Programmable design and self assembly of peptide conjugated AIEgens for biomedical applications

Ni-Yuan Zhang, Xing-Jie Hu, Hong-Wei An, Jian-Xiao Liang and Hao Wang

Biomaterials, 2022, 287, 121655
DOI: 10.1016/j.biomaterials.2022.121655

Progress in glycosylated aggregation-induced emission materials

Guangjian Liu, Gaili Feng, Xiafen Li, Yichen Liu, Wei Zhou, Yanming Ji, Yuan Zhang and Guowen Xing

Sci. Sin.-Chim, 2022, 52, 880
DOI: 10.1360/SSC-2021-0268

Phototherapeutic antibacterial applications of AIE-active antibiotic photosensitizer

Daran Li, Zhi-Hao Li, Saiya Yang, Gharibifalahieh-Anis, Nininahazwe-Lauraine, Maxwell Ampomah-Wireko, Cedric Dzidzor Kodjo Amengor, Ya-Na Wang and En Zhang

Bioorganic Chemistry, 2026, 170, 109542
DOI: 10.1016/j.bioorg.2026.109542

In vivo, clinical and translational aspects of aggregation-induced emission

Dingyuan Yan, Dong Wang and Ben Zhong Tang

Nat Rev Bioeng, 2025, 3, 976
DOI: 10.1038/s44222-025-00342-1

Expanding Our Horizons: AIE Materials in Bacterial Research

Michelle M. S. Lee, Eric Y. Yu, Joe H. C. Chau, Jacky W. Y. Lam, Ryan T. K. Kwok and Ben Zhong Tang

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202407707

New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Haoyue Wu, Yuanfeng Li, Linqi Shi, Yong Liu and Jing Shen

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202403206