Targeting the IDO1 pathway in cancer: from bench to bedside

Ming Liu, Xu Wang, Lei Wang, Xiaodong Ma, Zhaojian Gong, Shanshan Zhang and Yong Li

J Hematol Oncol, 2018, 11
DOI: 10.1186/s13045-018-0644-y

Discovery of novel IDO1 inhibitors via structure-based virtual screening and biological assays

Huizhen Ge, Longfei Mao, Jie Zhao, Yuwei Wang, Danfeng Shi, Xing Yang, Xiaorui Wang, Huanxiang Liu and Xiaojun Yao

J Comput Aided Mol Des, 2021, 35, 679
DOI: 10.1007/s10822-021-00386-6

Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model

Bin Luo, Zu-jun Que, Zhi-yi Zhou, Qing Wang, Chang-sheng Dong, Yi Jiang, Bing Hu, Hui Shi, Yu Jin, Jian-wen Liu, He-gen Li, Lin Wang and Jian-hui Tian

Journal of Integrative Medicine, 2018, 16, 283
DOI: 10.1016/j.joim.2018.04.008

HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation

Avisankar Chini, Prarthana Guha, Ashcharya Rishi, Nagashree Bhat, Angel Covarrubias, Valeria Martinez, Lucine Devejian, Bao Nhi Nguyen and Subhrangsu S. Mandal

Langmuir, 2025, 41, 11253
DOI: 10.1021/acs.langmuir.4c03005

The Multifaceted Role of Heme in Cancer

Veronica Fiorito, Deborah Chiabrando, Sara Petrillo, Francesca Bertino and Emanuela Tolosano

Front. Oncol., 2020, 9
DOI: 10.3389/fonc.2019.01540

Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma

Egarit Noulsri and Surada Lerdwana

Medical Hypotheses, 2022, 165, 110907
DOI: 10.1016/j.mehy.2022.110907

Nanomedicines modulate the tumor immune microenvironment for cancer therapy

Po-Han Chao, Vanessa Chan and Shyh-Dar Li

Expert Opinion on Drug Delivery, 2024, 21, 1719
DOI: 10.1080/17425247.2024.2412245

Trial watch: IDO inhibitors in cancer therapy

Julie Le Naour, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer and Erika Vacchelli

OncoImmunology, 2020, 9
DOI: 10.1080/2162402X.2020.1777625

Inhibition Mechanism of Indoleamine 2, 3-Dioxygenase 1 (IDO1) by Amidoxime Derivatives and Its Revelation in Drug Design: Comparative Molecular Dynamics Simulations

Xinyu Liu, Yiwen Zhang, Huaichuan Duan, Qing Luo, Wei Liu, Li Liang, Hua Wan, Shan Chang, Jianping Hu and Hubing Shi

Front. Mol. Biosci., 2020, 6
DOI: 10.3389/fmolb.2019.00164

Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders

Stefan W. Ryter

IJMS, 2021, 22, 5509
DOI: 10.3390/ijms22115509

Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer

Chunjing Wu, Sydney A. Spector, George Theodoropoulos, Dan J. M. Nguyen, Emily Y. Kim, Ashley Garcia, Niramol Savaraj, Diane C. Lim, Ankita Paul, Lynn G. Feun, Michael Bickerdike and Medhi Wangpaichitr

Cancer Metab, 2023, 11
DOI: 10.1186/s40170-023-00307-1

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer

Jiaqi Shi, Caiqi Liu, Shengnan Luo, Tingyu Cao, Binlin Lin, Meng Zhou, Xiao Zhang, Song Wang, Tongsen Zheng and Xiaobo Li

Cellular Immunology, 2021, 366, 104384
DOI: 10.1016/j.cellimm.2021.104384

Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies

Jingpu Zhang, Yanlei Liu, Xiao Zhi, Li Xu, Jie Tao, Daxiang Cui and Tie Fu Liu

Inflamm. Res., 2024, 73, 979
DOI: 10.1007/s00011-024-01878-5

Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-d]pyrimidin-4(5H)-one Scaffold

Ana Dolšak, Tomaž Bratkovič, Larisa Mlinarič, Eva Ogorevc, Urban Švajger, Stanislav Gobec and Matej Sova

Pharmaceuticals, 2021, 14, 265
DOI: 10.3390/ph14030265

Spiro-Oxindole Skeleton Compounds Are Efficient Inhibitors for Indoleamine 2,3-Dioxygenase 1: An Attractive Target for Tumor Immunotherapy

Daojing Yan, Jiakun Xu, Xiang Wang, Jiaxing Zhang, Gang Zhao, Yingwu Lin and Xiangshi Tan

IJMS, 2022, 23, 4668
DOI: 10.3390/ijms23094668

Prolactin Drives Iron Release from Macrophages and Uptake in Mammary Cancer Cells through CD44

Reagan Farrell, Nicholas Pascuzzi, Yi-Ling Chen, Mary Kim, Miguel Torres, Lauren Gollahon and Kuan-Hui Ethan Chen

IJMS, 2024, 25, 8941
DOI: 10.3390/ijms25168941

Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepaRG Tumor Cells

Hani Oweira, Imad Lahdou, Stefan Mehrle, Elias Khajeh, Rajan Nikbakhsh, Omid Ghamarnejad, Peter Terness, Christoph Reißfelder, Mahmoud Sadeghi and Ali Ramouz

JCM, 2022, 11, 4794
DOI: 10.3390/jcm11164794

Engineering New Branches of the Kynurenine Pathway To Produce Oxo-(2-aminophenyl) and Quinoline Scaffolds in Yeast

Michael Patrick Torrens-Spence, Chun-Ting Liu and Jing-Ke Weng

ACS Synth. Biol., 2019, 8, 2735
DOI: 10.1021/acssynbio.9b00368

Inhibitory investigation of niacin derivatives on metalloenzyme indoleamine 2,3-dioxygenase 1 for its immunomodulatory function

Daojing Yan, Jiakun Xu and Xiangshi Tan

Metallomics, 2021, 13
DOI: 10.1093/mtomcs/mfab001

Structural Basis of Selective Human Indoleamine‐2,3‐dioxygenase 1 (hIDO1) Inhibition

Shaymaa Emam Kassab and Samar Mowafy

ChemMedChem, 2021, 16, 3149
DOI: 10.1002/cmdc.202100253

Reversing the immunosuppressive tumor microenvironment via “Kynurenine starvation therapy” for postsurgical triple-negative breast cancer treatment

Zengguang Liu, Jiaxin Yin, Tianyuan Qiu, Aijiang Liu, Yanan Yu, Shengcai Yang, Ziling Liu and Quanshun Li

Journal of Controlled Release, 2025, 383, 113832
DOI: 10.1016/j.jconrel.2025.113832